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Source: http://twitter.com/TheNewsSun/statuses/224484612242550784
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Monday, July 16, 2012
UAE ships first oil via Fujairah as Iran threats escalate
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Source: http://news.yahoo.com/uae-ships-first-oil-via-fujairah-iran-threats-122246189.html
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Sunday, July 15, 2012
Wednesday, July 4, 2012
Shingles vaccine among patients with psoriasis, RA not linked with increased risk of shingles
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 3-Jul-2012[ | E-mail |
Share ] Contact: Bob Shepard
Bshep@uab.edu
205-934-8934
JAMA and Archives Journals
CHICAGO Although some have suggested that patients receiving medication for immune-mediated diseases such as rheumatoid arthritis or psoriasis may be at increased risk of herpes zoster (HZ; shingles) shortly after receipt of the vaccine, an analysis that included nearly 20,000 vaccinated Medicare beneficiaries finds that the live zoster vaccine is not associated with an increased risk of HZ shortly after vaccination in patients currently treated with biologics, and that it is associated with a significantly reduced longer-term risk of HZ in patients with an immune-mediated disease, according to a study in the July 4 issue of JAMA.
"A live attenuated vaccine reduces HZ risk by 70 percent and 51 percent among immunocompetent individuals 50 to 59 years and 60 years and older in 2 randomized blinded trials, respectively," according to background information in the article. "The risk of HZ is elevated by 1.5 to 2 times in patients with rheumatic and immune-mediated diseases such as rheumatoid arthritis and Crohn's disease. This increase has been attributed to both the underlying disease process and treatments for these conditions." Currently, the Food and Drug Administration (FDA) and other organizations consider the live HZ vaccine to be contraindicated in patients receiving some immunosuppressive medications commonly used to treat these conditions, including all immune-modulating biologic agents and some nonbiologic immunosuppressive medications. The safety concern is that these individuals may develop varicella infection from the vaccine virus strain, the authors write.
Jie Zhang, Ph.D., of the University of Alabama at Birmingham, and colleagues, evaluated patients with immune-mediated diseases. The retrospective cohort study included 463,541 Medicare beneficiaries 60 years and older with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis (a form of chronic inflammation of the spine), or inflammatory bowel disease using Medicare claims data from January 2006 through December 2009. The researchers measured the incidence rate of herpes zoster within 42 days after vaccination (a safety concern) and beyond 42 days.
The average age of the patients at the start of follow-up was 74 years, with the median (midpoint) duration of follow-up being 2 years; 72 percent of the patients were women, and 86 percent were white. During the study, 18,683 patients (4.0 percent) received the zoster vaccine.
The researchers found that among 633 patients exposed to biologics, including 551 patients exposed to anti-tumor necrosis factor (TNF) biologics, no cases of varicella or HZ occurred within the 42 days following vaccination. Among all patients, only 1 case of primary varicella was identified within the 42-day risk window, occurring on day 10 after vaccination.
During the period of more than 42 days after vaccination, the researchers observed 138 HZ cases. After controlling for demographics, type of immune-mediated disease, health care utilization, and exposure to biologic and nonbiologic disease-modifying antirheumatic drugs (DMARDs) and oral glucocorticoids, data indicated that vaccination was associated with decreased HZ risk over a median of 2 years of follow-up.
"Despite the recognition that patients with immune-mediated conditions are at increased risk of HZ, this and previous studies have shown that only a small fraction of these patients received the vaccine, likely in part due to safety concerns. Our data call into question the current recommendations that HZ vaccine is contraindicated in patients receiving biologics and suggest a need for a randomized controlled trial to specifically address the safety and effectiveness of HZ vaccination among patients receiving biologics," the authors conclude.
###
(JAMA. 2012;308[1]:43-49. Available pre-embargo to the media at http://media.jamanetwork.com)
Editor's Note: This project was supported by the Agency for Healthcare Research and Quality (AHRQ). Dr. Zhang received support from the AHRQ, and Dr. Curtis received support from AHRQ and the National Institutes of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.
To contact corresponding author Jeffrey R. Curtis, M.D., M.S., M.P.H., call Bob Shepard at 205-934-8934 or email Bshep@uab.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 3-Jul-2012[ | E-mail |
Share ] Contact: Bob Shepard
Bshep@uab.edu
205-934-8934
JAMA and Archives Journals
CHICAGO Although some have suggested that patients receiving medication for immune-mediated diseases such as rheumatoid arthritis or psoriasis may be at increased risk of herpes zoster (HZ; shingles) shortly after receipt of the vaccine, an analysis that included nearly 20,000 vaccinated Medicare beneficiaries finds that the live zoster vaccine is not associated with an increased risk of HZ shortly after vaccination in patients currently treated with biologics, and that it is associated with a significantly reduced longer-term risk of HZ in patients with an immune-mediated disease, according to a study in the July 4 issue of JAMA.
"A live attenuated vaccine reduces HZ risk by 70 percent and 51 percent among immunocompetent individuals 50 to 59 years and 60 years and older in 2 randomized blinded trials, respectively," according to background information in the article. "The risk of HZ is elevated by 1.5 to 2 times in patients with rheumatic and immune-mediated diseases such as rheumatoid arthritis and Crohn's disease. This increase has been attributed to both the underlying disease process and treatments for these conditions." Currently, the Food and Drug Administration (FDA) and other organizations consider the live HZ vaccine to be contraindicated in patients receiving some immunosuppressive medications commonly used to treat these conditions, including all immune-modulating biologic agents and some nonbiologic immunosuppressive medications. The safety concern is that these individuals may develop varicella infection from the vaccine virus strain, the authors write.
Jie Zhang, Ph.D., of the University of Alabama at Birmingham, and colleagues, evaluated patients with immune-mediated diseases. The retrospective cohort study included 463,541 Medicare beneficiaries 60 years and older with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis (a form of chronic inflammation of the spine), or inflammatory bowel disease using Medicare claims data from January 2006 through December 2009. The researchers measured the incidence rate of herpes zoster within 42 days after vaccination (a safety concern) and beyond 42 days.
The average age of the patients at the start of follow-up was 74 years, with the median (midpoint) duration of follow-up being 2 years; 72 percent of the patients were women, and 86 percent were white. During the study, 18,683 patients (4.0 percent) received the zoster vaccine.
The researchers found that among 633 patients exposed to biologics, including 551 patients exposed to anti-tumor necrosis factor (TNF) biologics, no cases of varicella or HZ occurred within the 42 days following vaccination. Among all patients, only 1 case of primary varicella was identified within the 42-day risk window, occurring on day 10 after vaccination.
During the period of more than 42 days after vaccination, the researchers observed 138 HZ cases. After controlling for demographics, type of immune-mediated disease, health care utilization, and exposure to biologic and nonbiologic disease-modifying antirheumatic drugs (DMARDs) and oral glucocorticoids, data indicated that vaccination was associated with decreased HZ risk over a median of 2 years of follow-up.
"Despite the recognition that patients with immune-mediated conditions are at increased risk of HZ, this and previous studies have shown that only a small fraction of these patients received the vaccine, likely in part due to safety concerns. Our data call into question the current recommendations that HZ vaccine is contraindicated in patients receiving biologics and suggest a need for a randomized controlled trial to specifically address the safety and effectiveness of HZ vaccination among patients receiving biologics," the authors conclude.
###
(JAMA. 2012;308[1]:43-49. Available pre-embargo to the media at http://media.jamanetwork.com)
Editor's Note: This project was supported by the Agency for Healthcare Research and Quality (AHRQ). Dr. Zhang received support from the AHRQ, and Dr. Curtis received support from AHRQ and the National Institutes of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.
To contact corresponding author Jeffrey R. Curtis, M.D., M.S., M.P.H., call Bob Shepard at 205-934-8934 or email Bshep@uab.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-07/jaaj-sva062812.php
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Tuesday, June 26, 2012
Video: The Europe Factor: General Motors & Ford
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NYC can end housing subsidies for homeless: appeals court
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Ousted Paraguay leader accuses lawmakers of 'coup'
Paraguay's ousted leader Fernando Lugo on Sunday accused lawmakers of carrying out a "parliamentary coup d'etat" to force him from power, as international protests mounted over his abrupt removal.
In his first public appearance since his impeachment on Friday over a deadly land dispute earlier this month, Lugo again blasted Congress for its snap decision but said he would nevertheless accept it in the name of peace.
"Lugo has not been dismissed; democracy has been dismissed. They have not respected the popular will," the ousted leader said in an unexpected appearance at a street protest attended by about 500 people in the capital Asuncion.
He called his impeachment "unjust" and called for "peaceful" demonstrations in the impoverished, landlocked South American nation.
"There was a parliamentary coup d'etat... the arguments for impeachment had no value," the 61-year-old former leader said after entering the studio of TV Publica, scene of the protest, for a brief news conference.
In a 39-4 vote, lawmakers on Friday found Lugo guilty of performing his duties badly during the armed clash on June 15 that claimed the lives of six police and 11 squatters on a privately-held farm.
His vice president Federico Franco was quickly sworn in to cheers in the Congress as Paraguay's new leader.
Lugo acknowledged that it would be "very difficult" to return in power, but said there should be no more violence, adding: "Peacefully, the democratic process will continue, with more strength."
Franco on Saturday told AFP in an interview in his office that he hoped Lugo would help him stem the international outcry over the change in power.
"Right now I'm trying to speak with president Lugo. I'm going to do it. I think his presence as a Paraguayan is very important to give an international image, because right now we need a legally constituted government," he said.
Franco said he planned to ask Lugo "to help us prevent Paraguay from receiving an absolutely unjust, unnecessary and unpopular punishment."
No foreign government has recognized Paraguay's new leadership.
Brazil, Argentina and Uruguay -- Paraguay's partners in the Mercosur trading bloc -- recalled their ambassadors for consultations.
The secretary general of the Organization of American States, Jose Miguel Insulza, called the snap impeachment a "disrespect to due process."
Insulza said the Americas had once again witnessed "a summary judgment that, while formally in keeping with the law, did not appear to fulfill all the legal precepts of the right to a legitimate defense."
Franco, who served as Lugo's vice president, earlier defended the ouster of his predecessor as being in compliance with the country's constitution, and he insisted "there was no coup."
"There are no soldiers in the street," he added.
But he acknowledged he was concerned about the international reaction.
"We will make our best efforts to get in touch with neighboring countries to try to demonstrate our clear commitment to democracy," he said.
Franco met earlier with the Vatican's envoy Agustin Arietti, and with the German ambassador Dirk Niebel, who said Berlin viewed the ouster as "a normal change of government, not by means of elections, but a normal process."
Lugo's lawyers had just two hours to present their case on his behalf in the Senate impeachment trial.
The torrent of furious responses to the ouster came not just from traditional leftist allies like Bolivia, Nicaragua and Venezuela.
Argentina's President Cristina Kirchner took to her Twitter account to repeat that "Argentina will not validate the coup in Paraguay."
"It's a travesty of justice and an affront to the rule of law to remove a president in 24 hours, with no guarantees to defend himself," the executive secretary of the Inter-American Commission on Human Rights, Santiago Canton, told a press conference.
The first major international event the new government had been expected to attend is a Mercosur summit in Argentina on Thursday and Friday.
But Franco told AFP he would not go if his presence would make matters worse.
Peru said it had offered to host a presidential summit of Mercosur leaders next week to assess the situation in Paraguay.
Brazil said members of Mercosur and Unasur, another regional bloc, were considering what measures should be applied to Paraguay in light of the developments.
Franco noted that any blockade of Paraguay would hurt Brazilian entrepreneurs, who have major interests in the country. Sixty percent of Paraguay's trade is with Brazil.
Extremely popular at the time of his election in 2008, Lugo -- a former priest -- saw his reputation in this predominantly Catholic country take a nosedive by repeated claims he fathered children while under a vow of chastity.
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